My primary use case is safeguarding my important personal artifacts (family photos, digitized paperwork, encryption key / account recovery / 2FA backups) against drive failure (~2TB), followed by my decently sized Plex server (23TB), immich, nextcloud, and various other small things like selfhosted bitwarden, grocy, ollama, and stuff like that.
I run all of my stuff off of a 6 bay Synology (more drives helps with capacity efficiency as double redundancy with 6 drives costs you 30% and I wanted to be protected against drive failures during rebuilding) with an Intel nuc on top to run plex/jellyfin transcoding using quicksync instead of loading the poor nas with cpu transcoding, I also run ollama on the nuc since it has faster cores than the nas.