hmmm. To be honest, that’s an okay summary out of context, but it really fails to grasp the essence of the paper. It’s not wrong per say, but it adds irrelevant details while withholding key information. I wouldn’t rely on chatgpt’s summary for this.
There’s a feature of some Long COVID cases (~50%) which is also the defining feature of an illness called ME/CFS which has been caused by various forms of viral infections throughout history. (It is thought that a lot of Long COVID cases are ME/CFS). Anyways this feature is, Post-Exertional Malaise, a worsening of the illness after exertion beyond a certain threshold, which can entail hundreds of symptoms and be permanent.
This paper is a review of some of the biomedical studies looking at what could possibly cause this, and finds there is repeated data of Microvascular (blood vessels) and immunometabolic (metabolic markers relating to immune function) differences with healthy controls.
The leading hypotheses are that this is caused by mitochondrial dysfunction which is mediated by a dysregulated immune system.
Some of my colleagues were co-authors on this paper. I’ll forward the feedback that it is jargony.
Background A considerable number of patients who contracted SARS-CoV-2 are affected by persistent multi-systemic symptoms, referred to as Post-COVID Condition (PCC). Post-exertional malaise (PEM) has been recognized as one of the most frequent manifestations of PCC and is a diagnostic criterion of m...
Background
A considerable number of patients who contracted SARS-CoV-2 are affected by persistent multi-systemic symptoms, referred to as Post-COVID Condition (PCC). Post-exertional malaise (PEM) has been recognized as one of the most frequent manifestations of PCC and is a diagnostic criterion of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Yet, its underlying pathomechanisms remain poorly elucidated.
Results
Upon physical activity, affected patients exhibit a reduced systemic oxygen extraction and oxidative phosphorylation capacity. Accumulating evidence suggests that these are mediated by dysfunctions in mitochondrial capacities and microcirculation that are maintained by latent immune activation, conjointly impairing peripheral bioenergetics. Aggravating deficits in tissue perfusion and oxygen utilization during activities cause exertional intolerance that are frequently accompanied by tachycardia, dyspnea, early cessation of activity and elicit downstream metabolic effects. The accumulation of molecules such as lactate, reactive oxygen species or prostaglandins might trigger local and systemic immune activation. Subsequent intensification of bioenergetic inflexibilities, muscular ionic disturbances and modulation of central nervous system functions can lead to an exacerbation of existing pathologies and symptoms
What kind of stuff would you encourage posting?
Interesting studies, relevant resources? Or would you prefer discussion type posts?
Or all of the above?
Cool yeah!
I’m really passionate about my field. And a lot of medical professionals have prejudice or believe outdates stereotypes about it. So I’d love to make some posts about it if that’s okay?
Hey I have a MD with residency in Neurology. Then I did a PhD in Neuroimmunology with board certification.
I’m currently doing a hectic mix of teaching two med courses, working on Long COVID research (biomarkers), and working in an understaffed long COVID (now post-viral disease) clinic.
Nice to meet you.
I mostly lurk on lemmy, but that’s because I haven’t found a place I’d like to consistently contribute yet. Maybe here?
LolAh sorry, the genome of octopus’ mating is only 99.99 something % similar. Not 100%. Rounding reflex.
Are octopus related to octopus? I mean technically they’re 100% related, but also they aren’t related as related implies not being. Depends on your interpretation.
I found college classes with small sizes were the worst as they would always adapt to the slowest learners who put no effort. While large lectures don’t do that.
Look up plague poems on bluesky, was posted yesteday author provided source in replies iirc
If you’re healthy.
Sucks to be disabled or immunocompromised or at risk in any other way…
Also, it’s still killing at much higher rates than the flu.
And I won’t even start getting into Long COVID, which I’m currently researching. But it is a major crisis. 2-4 million people unable to work in the US because of it.
FYI, you seem to be new here and seem not to be far-left. For your future enjoyment of lemmy, note that Lemmy.ML is a communist instance and therefore you may not like some of the content there.
When I was into gym and building muscle mass this confused the hell out of me at first.
Not really.
There have been extensive sociological studies over this. Condition in a capitalist society and the promotion of the “homo economicus” model continually reinforces “greediness” and leads to people in capitalist societies being far “greedier” on average.
It isn’t a natural thing, it is conditioned. Obviously everyone is greedy to an extent. But in anthropological examinations of different forms of societies, altruism scored far higher than greediness in non-capitalistic societies.
Kate Raworth, Oxford Economist, wrote an excellent chapter about this in her book called “doughnut economics”. The chapter is “Nurture Human Nature”.
The view that all humans are greedy and rational was promoted by Adam Smith and John Stuart Mill and is the precursing foundation of capitalism. But modern economics have rejected this view as it has been proven to be inaccurate, and increasingly rely on theoretical models built within behavioural economics.
Critical of capitalism ≠ Socialist
There’s a lot of nuance you’re missing out on in this simplistic statement.
I obviously oppose any authoritarian regime regardless of the economic system.
Does this statistic include calories fed to livestock or not?
Lac Léman, is the french word for what english people call lake geneva (all the region around lac léman is french speaking).
Léman comes from celtic “lemann” which means lake.
So lac léman is the lake lake. Given it is the biggest lake in western europe, not a bad name.