I promise you I have done exactly that, i had an auto clicker bound to my space bar and was to lazy to click and would just hold the space bar down when I knew that I was going to click a bunch of gui buttons.(which I though wouldnt be problem) Quickly learned some programs don't like it at all. Lol
I didn't have to work on it for just to not click through ui menus, I just had my autoclicker enabled from some reason(likely game) and just randomly thought, "I'll use the autoclick, lol" and had some interesting stuff happen. It was entertaining and nothing about being practical.