Honestly, the biggest challenge for me was self-motivation while severely depressed. I could show up to class, but that pretty much used up all the juice. Sometimes I wouldn't even be able to do that.
When you take a non-academically challenging degree and get told "lol just Google it" by a professor when you ask how to do a specific part of an assignment correctly after being told "nah you did it wrong"
(Totally didn't happen to me and why I dropped out I swear)