Frostbite can occur at temperatures just below freezing (-0.55°C or 31.01°F), though at such temperatures frostbite is typically mild and no permanent damage will result.
Oh, we have lots of those! There are some drugs that we use to treat high blood pressure work by causing vasodilation.
What's really interesting about this new drug is:
"...iloprost is not only a vasodilator but also reduces oxidative stress, suggesting this dual mechanism of action could help explain its impressive potential as a frostbite treatment."
It not only dilates blood vessels, it also directly treats reperfusion injury, which is really neat.