Last 25 years I have been using a couple of different tiling window managers.
My main workstations usually have four monitors, accessed by AltGr+number.
I heavily base my workflow on virtual desktops, accessed by Ctrl+number.
Each virtual desktop have a specific type of programs on it:
Development
Terminals
Browsers
Communication / documentation
Multimedia
Graphics
SQL
Debugging
Email
Virtual machines / monitoring
So with this I can access nearly every program with AltGr+number, Ctrl+number which is quite quick.
As long as I remember the monitor I placed it on, I always know which virtual desktop.
The chaining allows me to easier remember shortcuts with mnemonics, and they are fast enough, especially considering the amount of shortcuts I can scale it to.
Alt+T to start the chain, L for Layout, R for Resize.
Alt+T, R for Run, I for Inkscape.
Alt+T, A for Audio, N for Next.
There are some exceptions for the most used focus- and window moving operations, as well as for managing a clipboard buffer system.
There are too many times when one goes back and forth to copy something, paste it somewhere else and going back for the previous one.
So I can copy something, press Ctrl+Shift+3 to put in buffer 3. After a few other copy/pastes, I bring it into clipboard again with Ctrl+Alt+3.
This also allows me to for example reload a page I'm working on and login with user/pass easily accessible in buffer 1 and 2, or login to four different network devices again and again without going to a text file and copying one of four passwords each and every time.
I wrote a special session manager via socket for i3 to be able to press Ctrl+number and go to a certain predefined desktop on the current monitor I'm at.