Researchers have established a first potential therapeutic target for a type of early-onset dementia. Most neurodegenerative diseases, including dementias, involve proteins aggregating into filaments called amyloids. In most of these diseases, researchers have identified the proteins that aggrega
But, in around 10% of cases of frontotemporal dementia, scientists had yet to identify the rogue protein. Now, scientists have pinpointed aggregated structures of the protein TAF15 in these cases.