What are some downsides to immortality that most don't think of?

I'll start off with one, Being upset about a breakup that happened hundreds of years ago.

Edit 1:

Heath death of the universe, Death of the sun, etc, does not count. I feel like focusing on this is an overused point.

Edit 2:

Loneliness does not count. I feel like we all know immortality means you'll miss people and lose them.

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If other people are also immortal, the awkwardness of all of them eventually becoming your exes
- "Hey, we talked about this. You stick with the 52 states while I herd my broken heart down south"

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