What are some downsides to immortality that most don't think of?

I'll start off with one, Being upset about a breakup that happened hundreds of years ago.

Edit 1:

Heath death of the universe, Death of the sun, etc, does not count. I feel like focusing on this is an overused point.

Edit 2:

Loneliness does not count. I feel like we all know immortality means you'll miss people and lose them.

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If the ultra rich find you out, you can expect lab-rat life, at least until all modern systems collapse. Death is the only thing those suckers fear, because regardless of their net worth, it comes for all, even if late. They would do anything to find out your trick

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