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Photoshop and Lightroom.
You can run both, but especially Lightroom is a bit slow especially when using RAW files. LR is slow even on Windows :'(
Correct me if I'm wrong, but last I checked the Creative Cloud manager/installer for Adobe apps doesn't work on Wine, because it uses the windows system webview that Wine hasn't fully replicated. Only pirated copies or installations copied from a Windows machine work.
Fair enough, that might be true. I bought the creative suite back in the day for $2700 and those motherfuckers changed the whole business model like a year later, rendering that investment useless, so after that I vowed to never pay a red cent to adobe again.
Gimp/krita and darktable?
Those aren’t drop-in replacements. GIMP for example doesn’t have anything close to Photoshop’s content-aware fill capabilities, I don’t think Krita does either.