Keeping the discussion of running Windows applications through Wine/Proton aside; there are a lot of little things which happen to annoy me while I am using my PopOS install for example the most recent one is my headphones don't play any sound from the left year, it works properly on my other devices...
I'm willing to make it work, but most general users wouldn't be. This statement continues to be true even after the huge amounts of progress Linux community has made to make a better experience.