Tbh, I haven't experienced too many issues other then modifying a couple prgrams to be compatible with OpenRC. On my main desktop I use Debian 12 and Systemd with my 2080 SUPER and haven't encountered any issues.
Although, when I tried to install the open kernel version of the NVIDIA driver, my system didn't like it, so I ended up installing the full proprietary driver and it works well. Will be switching to AMD once I need to buy another graphics card.
(I use Gnome as my DE with two 1440p 144hz monitors)
Wait, you use Unstable? My favorite DM still does, but basically noone is both tech savvy enough, and crazy enough to use Unstable Debian. That's just a Sisyphean task.
The guys that run Unstable Debian end up creating bug reports like this: