For desktops it doesn't make much sense, but now everything's so oriented to systemd its actually starting to affect embedded Linux applications... so lets try our best to keep the alternatives alive.
I'm on Guix which doesn't use SystemD. Running on an MSI GS66 Stealth laptop with an Nvidia RTX¹ 3080. I browse the web, develop, run Stable Diffusion on the GPU, game using Steam and Lutris (Chivalry 2 and Diablo 4), Zoom calls for work.