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I don't think I could ever go back to a single monitor setup. Screen real estate is ALWAYS at a premium. I feel so constrained when forced to use just one.
Are you using a 1080p display?
I have a single 2k monitor and have gotten rid of my second monitor thanks to the real estate it offers. I've always wanted to have a large 4k TV as a main display and have my 2k monitor for games requiring fast response time.
My work setup is close to that, I use a 43 inch 4k. Each quadrant is effectively a 22 inch HD display. But I still have a second HD monitor because sometimes you need that logical separation. I tried 2 43 inch monitors but it made my neck hurt, lol.
My gaming rig is two ultrawides stacked on top of each other with vertical HD monitors on each side.