I feel obligated to note at the top that you can win...
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She set a tone at the very start when she walked right into his space to shake his hand and made him almost pull back into himself in response. She was in charge and never stopped being in charge.
Harris also managed what neither Joe Biden nor Hillary Clinton nor any of the 2016 Republicans managed to do which is successfully bait Donald Trump and get under his skin. Within a few minutes Trump was visibly angry and not in a way that empowered him but in a way that made him lose focus, go down rabbit holes and generally go off onto damaging tangents. Spittle anger, not righteous anger, shall we say.
And yet, none of it will matter because anyone who had even been considering voting for the racist cheeto is infinitely entrenched and bound by their own logic.
Indeed, and note that Harris didn't even attempt to go after his voters. The target is the middle and the squishy left, a reminder of what the stakes are in this election. She made it clear he was a petulant child, only caring about himself and the things important to him, and invited voters who want someone who doesn't just care about themselves to come out and vote for her.
Hopefully it's effective, because Trump has Project 2025 ready to go, despite his lies saying he knows nothing about it.