It just had its first Stable release (as Vanilla OS 2). Therefore, consider to wait it out a bit until it has been well-tested at large. Until then, please feel free to choose something else that is to your liking. Like, what is it that attracted you to this one in the first place?
It would be largely fine, but be careful. Being immutable, a lot of things that you would expect will work differently or not at all. I would not recommend it, but if you're in for a challenge, it's not bad.
I can vouch for Bazzite. It's at the point where you don't really have to do any tinkering. The only thing I really had to configure some extra beyond the defaults was pipewire, allowing different sample rates for my USB audio DAC.
You have to spend a few seconds to actually learn how the apps install. By default you can only install flatpaks but they have containers to install apps from any distro too. You can't install apps natively unless you use one extra command.