Soulfulginger @ Soulfulginger @lemmy.world

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2 yr. ago

*we'll know next month

The pancreas is not really stable enough to be implanted in at all. Other organs you're imagining like liver, stomach, heart, etc. have a solid lining that can be cut open and stitched back together. The pancreas is more like a cluster of loose cells with veins throughout and held together by a very thin, tissue paper lining. If you try to open it and insert cells, you're not going to be able to put it back together.

That's why cells are usually put in the liver, which has a large vein going directly to the pancreas. Close proximity and high blood supply. Implanting in the pancreas will likely never be an option unless you can drastically reduce the volume of cells.

Our lab was working on implanting the stem cells on a porous scaffold in the fat pad of the stomach as an alternative

Unfortunately, that doesn't necessarily negate the requirement for immunosuppresors or some other kind of immuno protection. If it is Type 1 diabetes, the person originally became diabetic because the immune system saw certain markers on the beta cells (insulin producing cells) as a threat. So, if you recreate the beta cells, there is still a possibility that it will happen again. You are fighting your own immune system. Someone in our lab was studying encapsulation of cells to create a protective barrier around them for this very issue

If the person was Type 2, this might be less of a risk since type 2 can also be due to high insulin resistivity. There are a lot of other factors involved, though, it's not straightforward

I literally worked in a research lab working on islet cell therapies for diabetes in the US. This has actually been done many times before with cells from cadavers. It has been successful, although most the of the time the person reverts back after a few years

The issues we were trying to solve in the lab were

1. Finding a good place to transplant where the cells will last: Implanting in the hepatic region (liver), which is the most common place to implant, is toxic to the cells over time hence only lasting 3-5 years. The cells need a really good blood supply and the volume you're transplanting can't be easily transplanted in the pancreas or kidney capsules (where many successful studies were performed in mice and rats)
2. Being able to consistently make a high volume of stem cells that are fully grown into insulin producing cells: Cadaver cells usually require 3-5 donors for 1 person and require the receiver to be on lifelong immunosuppresors due to the immune response. Depending on the kind of stem cells, the patient may still even need immunosuppresors due to the cell type you're converting from

All this the say - the article says nothing about where the cells where transplanted, where they came from, or whether the person has Type 1 or Type 2 diabetes. Although it is still a feat, it is likely not the first time it has been done, and we're still a long ways off from a cure

Dr. Death was about gross negligence in medicine and the failure of the medical system to prevent unqualified doctors from making it through the system. There's no evidence that this study has anything to do with that

Wubby7

None of those are mammals...

Don't forget about all the Harold and Kumars, pineapple express, basically every other movie with Seth rogan, all the bill and Ted's, Project x, role models, tropic thunder, horrible bosses, 21 jump street, etc. Some of these are also older, but I do think there are a lot more out there than you're listing

It's really inspiring to see such a wide range of hobbies in this thread

If you actually watch the documentary they also talk about 2 pedophiles who were on his set at nick and convicted during that time and one pedophile who was convicted from a disney set.

It's less about Dan schneider specifically (although he does seem to have a lot of unprofessional, sexist, and inappropriate mannerisms) and more about the need to increase protections for the physical and mental well being of child actors as a whole

The bad part is that their healthcare system still has to deal with the rising number of cases, but it's not like there has been an unexpected spike from anything unusual

For those who dont feel like reading the whole article, here's why:

"Much of the increase in kidney failure is caused by an ageing population. When age is taken into account, the number of people with kidney failure as a proportion of the population has remained fairly stable over the past decade, according to data from the registry."

I dont agree with their views, but I really dont think it's affecting their demand as much as you think. Lines are always insanely long - they just move them through very efficiently. By taking orders/payment as soon as you enter the line and knowing which car to give the food to when you get close to the window, the line never stops moving

I feel like Jimmy johns and chick fil a are the only truly fast restaurants anymore. For JJ you do have to go inside, but they often make your sandwich and complete payment in less than a minute, maybe 5 minutes max.

Meanwhile I've been to other drive throughs where even with very few people in line, it somehow takes 10/15 mins to get your meal. Plus, it's often incorrectly made and expensive

The room seems rather bleak at the moment with only gray and black colors and no decoration.

From an organization standpoint consider: getting some hangers for your clothes, hanging a curtain in front of the closet (if you dont want people to see your clothes), getting a bed frame, a bedside table. Have a very basic set of cleaning supplies (windex, paper towels, a swiffer for the floor)

Add some color to the room with a rug and/or throw blanket, and get a lamp if the room feels dark

Add things to the room that will bring you comfort when you walk in - some options are plants (can be fake to avoid watering), photos of family/friends/pets, posters or artwork, books/bookshelf, a television to watch from bed

I only like the smaller ones and hate the bigger ones

Some countries banned plastic microbeads in 2017, so a lot of those face washes changed the formula from plastics to environmentally friendly materials. They do still make them though

New fear unlocked

My experience may be too anecdotal to take into account, so I understand not caring about my specific experience. But I do think it's a good idea to take life span into account, and from a quick google search the average lifespan of a Macbook air is generally 5-7 years (so really not far off).

Just something to consider that since parts aren't replaceable, OP would have to pay the full amount of a new laptop at that time

I am not very familiar with framework but I did switch from macbooks to a dell gaming laptop years ago and I am so glad I did.

The macs are ridiculously expensive, and even if you break just the charger it costs a lot to replace. My laptop now I was able to get for nearly half the price and it runs games and programs that I used in college better than the mac ever could.

Every mac I ever owned completely died in 4-6 years of purchase. They're basically guaranteed to not last a long time. My guess is you're better off with getting a framework