Otter @ otter @lemmy.ca

I waddled onto the beach and ~~stole~~ *found* a computer to use.

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Yes we do :)

You can find the community for it at !pixelfed@lemmy.ca and read the post about the launch on !main@lemmy.ca

As for private accounts, my understanding is no. There is some discussion here: https://github.com/pixelfed/pixelfed/issues/1763

It is something that's being worked on, but I would advise holding off on posting anything that you want to keep truly private

Patient gets to keep their canine then.

That's a good point. I remember seeing an article about tooth re-growing teeth (in ferrets), and while I don't remember if it was stem cells, that might be nicer than having to lose a tooth for an eye.

Do you know if tissue grown from a patient’s own stem cells is generally not rejected by the immune system

My background is a bit limited here, but looking around it seems that it's 'better' but not necessarily 'rejection proof'

HSCT came to mind first, but those are replicated inside the patient:

Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells [...] in order to replicate inside a patient and produce additional normal blood cells. HSCT may be autologous (the patient's own stem cells are used), syngeneic (stem cells from an identical twin), or allogeneic (stem cells from a donor)

Autologous transplants have the advantage of lower risk of infection during the immune-compromised portion of the treatment, since the recovery of immune function is rapid. Also, the incidence of patients experiencing rejection is very rare (and graft-versus-host disease impossible) due to the donor and recipient being the same individual

Induced pluripotent stem cells seem closer:

Since iPSCs can be derived directly from adult tissues, they not only bypass the need for embryos, but can be made in a patient-matched manner, which means that each individual could have their own pluripotent stem cell line. These unlimited supplies of autologous cells could be used to generate transplants without the risk of immune rejection. While the iPSC technology has not yet advanced to a stage where therapeutic transplants have been deemed safe, iPSCs are readily being used in personalized drug discovery efforts and understanding the patient-specific basis of disease.

This other article from 2013 lists a few concerns, and I think this is the closest to what you were looking for: https://pmc.ncbi.nlm.nih.gov/articles/PMC3931018/#sec3

Potential Causes of iPSC Immunogenicity

[...] The first potential cause is immaturity of cells differentiated from iPSCs in vitro. [...] There are a number of human cell types that, to date, can be differentiated only to immature phenotypes in vitro [...] . An immature phenotype poses two risks for immune response, the first being low MHC class I (MHC-I) expression. Natural killer (NK) cells target cells with low MHC-I levels, and although differentiation of iPSCs causes these levels to rise, they may not reach those of adult tissue. [...] Another risk of an immature phenotype is expression of embryonic or fetal proteins. These antigens may not have been present during immune system education to go through negative selection in the thymus, leaving them susceptible to T cell attack. T [...].

A second potential cause of iPSC immunogenicity is genetic and epigenetic changes that arise from reprogramming or adaptation to culture conditions. Recent studies have demonstrated that reprogramming to pluripotency is incomplete and that iPSCs carry an epigenetic memory of their tissue of origin that affects gene expression and can restrict differentiation potential (26–30). [...]

A third potential cause is culturing of iPSCs, or their differentiated progeny, with xenogeneic or non-physiological culture reagents. [...] hESCs take up the non-human sialic acid N-glycolylneuraminic acid (Neu5Gc) from mouse cell feeder layers and animal serum-containing culture media. This represents a risk because humans have circulating antibodies to Neu5Gc (37). Several groups have since developed xeno-free culture conditions for reprogramming and differentiation that reduce or eliminate Neu5Gc expression, although these methods are costly and can be technically challenging (38–40). [...]

[...]

A fun fact I came across on that wikipedia article:

Yamanaka named iPSCs with a lower case "i" due to the popularity of the iPod and other products.

Odd, I'll see if we can figure out what might be happening

Oh interesting, good to know

Someone here should grab it before we end up with a situation like that other subreddit (either the 'save 3rd party apps' one or 'reddit alternatives'?) where the mods were removing posts promoting Lemmy/fediverse

I read it more as asking why a USB-C went with an oval shape instead of a circle

I don't mind, but it might be good to leave some details out of titles for casting decisions

This crosspost from !daredevil@lemmy.world for example

https://sh.itjust.works/post/33599966

[potential spoilers] Daredevil Born Again Season 2 casting

{details of spoiler}

Also there's a 'Shaggy in the MCU' joke in here somewhere

Amazing find 😊 the snowy fluff!

test

This is an old post, but I'm seeing the same issue @rikudou@lemmings.world

In my case it is self-hosted with docker, here is an example: https://lemmy.ca/post/39867153

Interestingly, sorting by new in the community only brings up one copy of the post, but both posts show up in the UI under 'crosspost', as well as in the user's post history: https://lemmy.ca/c/vancouver?dataType=Post&sort=New

One benefit we couldn't get from robots is the disease and medical knowledge we've gained from human space travel

https://www.asc-csa.gc.ca/eng/about/everyday-benefits-of-space-exploration/improving-health-care.asp

https://pmc.ncbi.nlm.nih.gov/articles/PMC9833174/

https://www.nasa.gov/missions/station/space-station-leads-to-breakthroughs-in-human-health-on-earth/

Some of these could have been done without space travel for sure, but it's hard to predict what we'll learn before we do things

Time travel interactions however, those could be a problem

It's odd that something is causing it to be unpinned afterwards. Is it unpinned everywhere that you've checked, or those instances in particular?

I'll pass this along to the others

Good to know :)

I'll see if we can make it more prominent, maybe in the instance sidebar, or by pinning more pixelfed.ca related announcements as they come up.

I worry about pinning things for too long, since it can crowd up people's feed and make them ignore the posts if they pop up too often. There's a balance to it, and we might have taken that one down too quickly

See the crosspost where someone commented a summary of the procedure

I have only tried Zen from your list and it's been nice so far. The most recent update last night broke something with the multi account containers, but other than that it's been smooth sailing for months.

Ladybird looks promising but it's not out yet. Planning to try switching to it when it's out.

Arc is apparently dead (or dying), but it was chromium based, VC funded, and Zen does most of the same things anyway. https://www.theverge.com/2024/10/24/24279020/browser-company-ai-browser-arc

The post count is broken, it's on our list of things to look into (unless it fixes itself after a month has passed 🤷)

It's been great on pixelfed, I appreciate the people that put some time into it