[PAPER] Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
[PAPER] Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
pmc.ncbi.nlm.nih.gov Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms that drive ageing remain largely unknown, impeding the development of interventions that might delay or prevent ...
This paper covers a potential causal link between cellular senescence and various aging phenotypes. Removing senescent cells exhibiting the kinase inhibitor and senescence biomarker p16 delayed the onset of age-related phenotypes in mouse skeletal muscle, adipose, and eye tissues.
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