Dustland Delivery is a post-apocalyptic survival business simulator. Scour the wastes for profit, complete missions to grow your trading empire, and assemble a rag-tag band of adventurers to turn your city into the capital of the Dustlands. Danger lurks around every corner—but no risk, no reward!
Played the EA release, haven't tried 1.0. Pretty good indie experience IMO.
Although you have to be into trading games to enjoy it. Also has solid RPG mechanics and some survival mechanics. I didn't get far, but there is an over-arching storyline as well.