Columbus Day Rule
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The colombian exchange made pizza possible, sooo...
Just the tomato base really. There was still a lot of pizza-like food that predated the columbian exchange because I guess it doesn't require much effort to invent "bread with stuff on it"
Tomato seems essential.
A lot of good pizza out there that don't use tomato as a base though. I love a good pesto pizza, and pesto uses all "old world" ingredients.