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Rotating a 2d being in 3d space would be trippy and probably lethal. A 2d being would have it's entire existence on a specific fixed 2d plane cutting through space- by rotating it, you've completely redefined the entire plane, and everything that the creature knew about and had built would be permanently lost.
Theoretically if you rotated the creature 180°, it could again perceive things from its own world, though in a very different way. But you'd think a sufficiently smart 2 dimensional creature could come to recognize that it was indeed the same world just mirrored.
Though it's possible this creature's chemistry would have a "handedness" and it could no longer metabolize the nutrients that exist in that world.
Hmmm, yeah I'd imagine chemistry would develop a specific handedness. It's a bizarre thing to think about