So, this comic is actually #5 in a 6-part series. One that's gone increasingly ridiculous as it's progressed.
The villain here is Lasso Man. The lasso tool is a selection tool, a way to select something by drawing around it, letting you do whatever you want to the selection. In this comic, Lasso Man is using his power to take parts of other people and add them onto himself, gaining their powers.
in panel 2, the guy in Green is Undo/Redo/whatever.
In panel 6, we get a few more characters. The guy in red is Slice, which is like an upgraded version of Crop. It's used to slice up an image into pieces that you can do stuff with.
The dude in orange with the purple helmet is presumably the Spraypaint function, which is a type of painting tool with a customizable "brush". The one with the drop I guess is Liquify, which is a type of filter that let's you distort images.
Panel 11 is confusing without context. See that purple arm? It belonged to Paint Bucket Man. He can fill in selected areas with a specific color. In this case, turning that woman solid "stone".
In panel 14, the dude uses Generative Fill, which can be best described as asking an AI to fill in this section, hence the weird finger results.
Finally, we've got the wizard up next. He uses the Magic Wand tool, which is another selection tool that basically uses "AI" to determine what you want to select. With this tool, you can adjust its tolerance to determine how little or how much it considers worth selecting. In this case, the wizard turns the tolerance all the way, telling it to as much as possible.
Scissor icon - used to cut part of the image. Also killed the bad guy in this case
Bad guy had the copy/paste icons so he just created new versions/clones of himself
Bad guy also has the “lasso” icon. This is used to select a random area of the image (the dashed lines creating circles, you can then do different things to just the area selected
Checkerboard patterns indicate the “canvas” or what the image sits on. So almost null space
Though the slice guy killed a clone, the bad guy caught him in part of a selection and basically moved his legs out from him (when you make a selection, you can do anything you want with it, including moving it somewhere else)
Generative fill takes a selected area and kind of repeats it (similar to copy/paste)
bad guy keeps selecting different sections of space to kill the people
wizard uses a feature called magic wand which usually selects an area of similar colors. The tolerance is how similar it is (great for trying to select the outline of a person on a backdrop for example, it’d be a pain to to it by hand, but if they were in front of a green screen it would select all green colors that are touching, by increasing the tolerance you say “green and anything that’s close to it too”)
once he’s selected that massively large area, he proceeds to delete it and everyone/everything in it.