You should only be using Ublock Origin and whatever additional filter lists you prefer. Every other additional adblocker leads to very limited returns on investment (including some adblockers which are proprietary!) and even breaking compatibility with sites if the adblocker is overzealous.
That's unfortunate, you still don't have to use chrome but can instead use ungoogled chromium, which is much safer and pretty much the only libre version of chromium out there.